PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae.
Sci Immunol
; 4(36)2019 06 14.
Article
em En
| MEDLINE
| ID: mdl-31201259
ABSTRACT
CD8+ tissue-resident memory T (TRM) cells provide frontline immunity in mucosal tissues. The mechanisms regulating CD8+ TRM maintenance, heterogeneity, and protective and pathological functions are largely elusive. Here, we identify a population of CD8+ TRM cells that is maintained by major histocompatibility complex class I (MHC-I) signaling, and CD80 and CD86 costimulation after acute influenza infection. These TRM cells have both exhausted-like phenotypes and memory features and provide heterologous immunity against secondary infection. PD-L1 blockade after the resolution of primary infection promotes the rejuvenation of these exhausted-like TRM cells, restoring protective immunity at the cost of promoting postinfection inflammatory and fibrotic sequelae. Thus, PD-1 serves to limit the pathogenic capacity of exhausted-like TRM cells at the memory phase. Our data indicate that TRM cell exhaustion is the result of a tissue-specific cellular adaptation that balances fibrotic sequelae with protective immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Infecções por Orthomyxoviridae
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Linfócitos T CD8-Positivos
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Antígeno B7-H1
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Receptor de Morte Celular Programada 1
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Memória Imunológica
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Pulmão
Limite:
Animals
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Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article