Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato.
Hum Immunol
; 81(9): 510-512, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31204089
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (Nâ¯=â¯78), León (Nâ¯=â¯22) and rural communities (Nâ¯=â¯162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64⯱â¯2.11% by ML, 43.35% of Native American haplotypes) and European (44.14⯱â¯1.14% by ML; 39.35% of European haplotypes), while African genetic component is less apparent (5.22⯱â¯2.08% by ML; 8.36% of African haplotypes).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Etnicidade
/
Genética Populacional
/
Antígenos HLA
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article