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Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening.
Duan, Zhe; Liu, Jingqiu; Niu, Liping; Wang, Jun; Feng, Mingqian; Chen, Hua; Luo, Cheng.
Afiliação
  • Duan Z; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  • Liu J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Niu L; Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.
  • Wang J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Feng M; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: fengmingqian@mail.hzau.edu.cn.
  • Chen H; Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China. Electronic address: hua-todd@hbu.edu.cn.
  • Luo C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: cluo@simm.ac.cn.
Bioorg Med Chem ; 27(15): 3229-3236, 2019 08 01.
Article em En | MEDLINE | ID: mdl-31208797
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Isocitrato Desidrogenase / NADP Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Descoberta de Drogas / Ensaios de Triagem em Larga Escala / Isocitrato Desidrogenase / NADP Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article