Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells.

Lin, Li; Wei, Hulai; Yi, Juan; Xie, Bei; Chen, Jing; Zhou, Cunmin; Wang, Li; Yang, Yue

Lin, Li; Wei, Hulai; Yi, Juan; Xie, Bei; Chen, Jing; Zhou, Cunmin; Wang, Li; Yang, Yue.

Afiliação

Lin L; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Wei H; Hematology Department, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China.
Yi J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Xie B; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Chen J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Zhou C; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Wang L; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Yang Y; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.

J Cell Biochem ; 120(10): 17635-17649, 2019 10.

Article em En | MEDLINE | ID: mdl-31209915

Assuntos

Antígenos de Bactérias/metabolismo; Proteínas de Bactérias/metabolismo; Células Epiteliais/patologia; Mucosa Gástrica/patologia; Infecções por Helicobacter/patologia; Helicobacter pylori/fisiologia; Mesoderma/patologia; Células-Tronco Neoplásicas/patologia; Animais; Apoptose; Linhagem Celular; Movimento Celular; Proliferação de Células; Células Epiteliais/microbiologia; Transição Epitelial-Mesenquimal; Feminino; Humanos; Metilnitronitrosoguanidina; Camundongos Endogâmicos C57BL; Via de Sinalização Wnt

Palavras-chave

C57BL/6 mice; CagA-positive Helicobacter pylori; Immortalized human gastric epithelial cells (GES-1); N-methyl-N'-nitro-N-nitrosoguanidine (MNNG); Wnt/ß-catenin signaling pathway; cancer stem cell-like properties; epithelial-mesenchymal transition (EMT)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Células-Tronco Neoplásicas / Helicobacter pylori / Infecções por Helicobacter / Células Epiteliais / Mucosa Gástrica / Mesoderma / Antígenos de Bactérias Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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