Assessment of serum galectin-3, methylated arginine and Hs-CRP levels in type 2 diabetes and prediabetes.
Life Sci
; 231: 116577, 2019 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-31211997
PURPOSE: Galectin-3 is associated with the process of inflammation and fibrosis. The aim of this study was both to evaluate of galectin-3, methylated arginines and hs-CRP in subjects with type 2 diabetes and prediabetes and to investigate a relation between serum galectin-3, methylated arginines and hs-CRP levels. METHODS: In this study, all subjects were defined as the control group, type 2 diabetes (nâ¯=â¯84) by fasting plasma glucose and prediabetes (nâ¯=â¯34) by 75-g oral glucose tolerance test. Also, participants with type 2 diabetes were divided into as group I (HbA1c ≤7%, nâ¯=â¯40) and group II (HbA1c ≥7%, nâ¯=â¯44). The analysis of serum methylated arginines levels was analyzed by tandem mass spectrometry. Galectin-3 levels were determined via chemiluminescent microparticle immunoassay (CMIA). RESULTS: Serum galectin-3, ADMA, L-NMMA and SDMA levels were significantly lower in the control group (13.3⯱â¯3.42; 0.630 (0.13-1.36); 0.176 (0.02-0.53); 0.115 (0.04-0.26), respectively) compared to diabetic subjects (15.71⯱â¯4.22; 0.825 (0.23-2.80); 0.366 (0.08-1.41); 0.1645 (0.06-0.47), pâ¯=â¯0.002, pâ¯=â¯0.01, pâ¯=â¯0.001 and pâ¯=â¯0.006, respectively). Galectin-3 was positively correlated with hs-CRP (râ¯=â¯0.295 pâ¯=â¯0.001), L-NMMA (râ¯=â¯0.181 pâ¯=â¯0.022), HbA1c (râ¯=â¯0.247 pâ¯=â¯0.002), neopterin (râ¯=â¯0.160 pâ¯=â¯0.045) and FPG (râ¯=â¯0.207 pâ¯=â¯0.001) respectively. Also, there was positively correlated ADMA with FPG (râ¯=â¯0.192 pâ¯=â¯0.016) and eAG (râ¯=â¯0.235 pâ¯=â¯0.003). CONCLUSIONS: Thus, galectin-3 might be a useful prognostic marker in the population with prediabetes and diabetes. Moreover, it can be a marker showing the condition of developing complications in diabetic patients.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
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Estado Pré-Diabético
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Proteína C-Reativa
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Galectina 3
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Diabetes Mellitus Tipo 2
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article