Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection.

Cao, Yu; Xiong, Da; Kong, Ruize; Dai, Guolin; Zhong, Minghua; Li, Li; Zhang, Jinping; Jiang, Lihong; Li, Hongrong

Cao, Yu; Xiong, Da; Kong, Ruize; Dai, Guolin; Zhong, Minghua; Li, Li; Zhang, Jinping; Jiang, Lihong; Li, Hongrong.

Afiliação

Cao Y; Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
Xiong D; Department of Cardiovascular Surgery, The First Peoples' Hospital of Yunnan Province, No. 157, Jinbi road, Kunming, Yunnan, People's Republic of China.
Kong R; Department of Cardiovascular Surgery, The First Peoples' Hospital of Yunnan Province, No. 157, Jinbi road, Kunming, Yunnan, People's Republic of China.
Dai G; Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
Zhong M; Institute of Basic Medicine of the First People's Hospital of Yunnan Province, Center of Clinical Molecular Biology of Yunnan Province, The First Peoples' Hospital of Yunnan Province, Kunming, Yunnan, People's Republic of China.
Li L; Department of Cardiovascular Surgery, The First Peoples' Hospital of Yunnan Province, No. 157, Jinbi road, Kunming, Yunnan, People's Republic of China.
Zhang J; Department of Cardiovascular Surgery, The First Peoples' Hospital of Yunnan Province, No. 157, Jinbi road, Kunming, Yunnan, People's Republic of China.
Jiang L; Institute of Basic Medicine of the First People's Hospital of Yunnan Province, Center of Clinical Molecular Biology of Yunnan Province, The First Peoples' Hospital of Yunnan Province, Kunming, Yunnan, People's Republic of China.
Li H; Institute of Basic Medicine of the First People's Hospital of Yunnan Province, Center of Clinical Molecular Biology of Yunnan Province, The First Peoples' Hospital of Yunnan Province, Kunming, Yunnan, People's Republic of China.

Mol Cell Biochem ; 460(1-2): 29-36, 2019 Oct.

Article em En | MEDLINE | ID: mdl-31214845

Assuntos

Aneurisma da Aorta Abdominal/patologia; Células Endoteliais/metabolismo; Óxido Nítrico/metabolismo; Proteína do Retinoblastoma/metabolismo; Transdução de Sinais; Tetra-Hidrofolato Desidrogenase/metabolismo; Animais; Aorta Torácica/metabolismo; Aorta Torácica/patologia; Aorta Torácica/fisiopatologia; Aneurisma da Aorta Abdominal/fisiopatologia; Artérias/metabolismo; Pressão Sanguínea; Regulação para Baixo; Células Endoteliais/patologia; Camundongos; Óxido Nítrico Sintase Tipo III/metabolismo; Prostaglandinas/metabolismo; Proteína do Retinoblastoma/deficiência; Remodelação Vascular; Vasoconstrição; Vasodilatação

Palavras-chave

Aortic aneurysm; DHFR; Endothelial; Rb; Rb1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetra-Hidrofolato Desidrogenase / Transdução de Sinais / Proteína do Retinoblastoma / Aneurisma da Aorta Abdominal / Células Endoteliais / Óxido Nítrico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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