Your browser doesn't support javascript.
loading
The ketogenic diet in children 3 years of age or younger: a 10-year single-center experience.
Kim, Se Hee; Shaw, Alexandra; Blackford, Robyn; Lowman, Wesley; Laux, Linda C; Millichap, John J; Nordli, Douglas R.
Afiliação
  • Kim SH; Epilepsy Center, Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA.
  • Shaw A; Department of Pediatrics, Division of Neurology, Epilepsy Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Blackford R; Epilepsy Center, Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA.
  • Lowman W; Department of Clinical Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, 60611, USA.
  • Laux LC; Department of Clinical Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, 60611, USA.
  • Millichap JJ; Epilepsy Center, Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA.
  • Nordli DR; Epilepsy Center, Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA. jmillichap@luriechildrens.org.
Sci Rep ; 9(1): 8736, 2019 06 19.
Article em En | MEDLINE | ID: mdl-31217425
The ketogenic diet (KD) is an effective treatment option for intractable epilepsy. Here, we reviewed the last 10 years of our experience with the KD and characterized its use in patients under 3 years of age. Medical records of all patients under the age of 3 years who were treated with the ketogenic diet from April 2004 to June 2014 were retrospectively reviewed. One hundred and nine patients with drug-resistant epilepsy were included. The mean age at the initiation of the KD was 1.4 ± 0.8 years old. The youngest patient was 3 weeks old. After 3 months, 39% (42/109) of patients responded to the KD and experienced more than 50% seizure reduction. Of those 42 patients, 20 (18%) achieved complete seizure control. Patients with a genetic etiology showed a better response to the KD in seizure reduction than the other patients (p = 0.03). Age at initiation of the KD was not related to eventual seizure outcome (p = 0.6). The KD continues to be an effective, safe, and well tolerated treatment option for infants with intractable epilepsy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Cetogênica / Epilepsia Resistente a Medicamentos Tipo de estudo: Observational_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta Cetogênica / Epilepsia Resistente a Medicamentos Tipo de estudo: Observational_studies Limite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2019 Tipo de documento: Article