Targeting the H3K4 Demethylase KDM5B Reprograms the Metabolome and Phenotype of Melanoma Cells.

Vogel, Felix C E; Bordag, Natalie; Zügner, Elmar; Trajkovic-Arsic, Marija; Chauvistré, Heike; Shannan, Batool; Váraljai, Renáta; Horn, Susanne; Magnes, Christoph; Thomas Siveke, Jens; Schadendorf, Dirk; Roesch, Alexander

Vogel, Felix C E; Bordag, Natalie; Zügner, Elmar; Trajkovic-Arsic, Marija; Chauvistré, Heike; Shannan, Batool; Váraljai, Renáta; Horn, Susanne; Magnes, Christoph; Thomas Siveke, Jens; Schadendorf, Dirk; Roesch, Alexander.

Afiliação

Vogel FCE; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Bordag N; Center for Biomarker Research in Medicine, CBmed GmbH, Graz, Austria.
Zügner E; Joanneum Research Forschungsgesellschaft mbH HEALTH - Institute for Biomedicine and Health Sciences, Graz, Austria.
Trajkovic-Arsic M; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
Chauvistré H; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Shannan B; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Váraljai R; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Horn S; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Magnes C; Joanneum Research Forschungsgesellschaft mbH HEALTH - Institute for Biomedicine and Health Sciences, Graz, Austria.
Thomas Siveke J; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
Schadendorf D; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany.
Roesch A; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium, University of Duisburg-Essen, Duisburg/Essen, Germany. Electronic address: alexander.roesch@uk-essen.de.

J Invest Dermatol ; 139(12): 2506-2516.e10, 2019 12.

Article em En | MEDLINE | ID: mdl-31229500

Assuntos

Regulação Neoplásica da Expressão Gênica; Histonas/genética; Histona Desmetilases com o Domínio Jumonji/genética; Melanoma/genética; Metaboloma/genética; Proteínas Nucleares/genética; RNA Neoplásico/genética; Proteínas Repressoras/genética; Neoplasias Cutâneas/genética; Linhagem Celular Tumoral; Proliferação de Células; Histonas/metabolismo; Humanos; Histona Desmetilases com o Domínio Jumonji/biossíntese; Melanoma/metabolismo; Melanoma/patologia; Proteínas Nucleares/biossíntese; Fenótipo; Proteínas Repressoras/biossíntese; Neoplasias Cutâneas/metabolismo; Neoplasias Cutâneas/patologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Neoplasias Cutâneas / RNA Neoplásico / Proteínas Nucleares / Histonas / Regulação Neoplásica da Expressão Gênica / Metaboloma / Histona Desmetilases com o Domínio Jumonji / Melanoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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