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Novel phase I trial design to evaluate the addition of cediranib or selumetinib to preoperative chemoradiotherapy for locally advanced rectal cancer: the DREAMtherapy trial.
Marti, F E Marti; Jayson, G C; Manoharan, P; O'Connor, J; Renehan, A G; Backen, A C; Mistry, H; Ortega, F; Li, K; Simpson, K L; Allen, J; Connell, J; Underhill, S; Misra, V; Williams, K J; Stratford, I; Jackson, A; Dive, C; Saunders, M P.
Afiliação
  • Marti FEM; The Christie NHS Foundation Trust, Manchester, UK.
  • Jayson GC; The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Manoharan P; The Christie NHS Foundation Trust, Manchester, UK; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
  • O'Connor J; The Christie NHS Foundation Trust, Manchester, UK; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
  • Renehan AG; The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Backen AC; The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Mistry H; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
  • Ortega F; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
  • Li K; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
  • Simpson KL; Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
  • Allen J; The Christie NHS Foundation Trust, Manchester, UK.
  • Connell J; The Christie NHS Foundation Trust, Manchester, UK.
  • Underhill S; The Christie NHS Foundation Trust, Manchester, UK.
  • Misra V; The Christie NHS Foundation Trust, Manchester, UK.
  • Williams KJ; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
  • Stratford I; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
  • Jackson A; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
  • Dive C; Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
  • Saunders MP; The Christie NHS Foundation Trust, Manchester, UK. Electronic address: Mark.Saunders@christie.nhs.uk.
Eur J Cancer ; 117: 48-59, 2019 08.
Article em En | MEDLINE | ID: mdl-31229949
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Protocolos de Quimioterapia Combinada Antineoplásica / Quimiorradioterapia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Protocolos de Quimioterapia Combinada Antineoplásica / Quimiorradioterapia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article