Generation of functional hepatocyte-like cells from human bone marrow mesenchymal stem cells by overexpression of transcription factor HNF4&#945; and FOXA2.

Xie, Pei-Yi; Hu, Xiao-Jun; Guo, Ruo-Mi; Meng, Xiao-Chun; Pang, Peng-Fei; Zhou, Zhi-Yang; Li, Dan; Shan, Hong

Generation of functional hepatocyte-like cells from human bone marrow mesenchymal stem cells by overexpression of transcription factor HNF4α and FOXA2.

Xie, Pei-Yi; Hu, Xiao-Jun; Guo, Ruo-Mi; Meng, Xiao-Chun; Pang, Peng-Fei; Zhou, Zhi-Yang; Li, Dan; Shan, Hong.

Afiliação

Xie PY; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Department of Radiology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
Hu XJ; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Medicine Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Radiology Institute, Sun
Guo RM; Department of Radiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Meng XC; Department of Radiology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
Pang PF; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Medicine Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Radiology Institute, Sun
Zhou ZY; Department of Radiology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
Li D; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Medicine Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Radiology Institute, Sun
Shan H; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Medicine Center, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China; Interventional Radiology Institute, Sun

Hepatobiliary Pancreat Dis Int ; 18(6): 546-556, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31230960

Assuntos

Diferenciação Celular; Fator 3-beta Nuclear de Hepatócito/metabolismo; Fator 4 Nuclear de Hepatócito/metabolismo; Hepatócitos/metabolismo; Células-Tronco Mesenquimais/metabolismo; Animais; Biomarcadores/metabolismo; Linhagem Celular; Proliferação de Células; Forma Celular; Feminino; Fator 3-beta Nuclear de Hepatócito/genética; Fator 4 Nuclear de Hepatócito/genética; Humanos; Camundongos Endogâmicos BALB C; Camundongos Nus; Transdução de Sinais; Transfecção; Regulação para Cima

Palavras-chave

Hepatic differentiation; Hepatocyte nuclear factor; Mesenchymal stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Hepatócitos / Fator 3-beta Nuclear de Hepatócito / Fator 4 Nuclear de Hepatócito / Células-Tronco Mesenquimais Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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