Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines.

Guo, Xiaofeng; Yang, Dongyan; Fan, Zhijin; Zhang, Nailou; Zhao, Bin; Huang, Chun; Wang, Fangjie; Ma, Rongji; Meng, Meng; Deng, Youcai

Guo, Xiaofeng; Yang, Dongyan; Fan, Zhijin; Zhang, Nailou; Zhao, Bin; Huang, Chun; Wang, Fangjie; Ma, Rongji; Meng, Meng; Deng, Youcai.

Afiliação

Guo X; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China.
Yang D; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China. Electronic address: yangdy@nankai.edu.cn.
Fan Z; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China. Electronic address: fanzj@nankai.edu.cn.
Zhang N; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China.
Zhao B; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, PR China.
Huang C; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Wang F; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Ma R; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Meng M; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address: keven190@sina.com.
Deng Y; Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address: youcai.deng@tmmu.edu.cn.

Eur J Med Chem ; 178: 767-781, 2019 Sep 15.

Article em En | MEDLINE | ID: mdl-31234030

Assuntos

Tirosina Quinase da Agamaglobulinemia/antagonistas & inibidores; Antineoplásicos/farmacologia; Descoberta de Drogas; Linfoma Difuso de Grandes Células B/tratamento farmacológico; Inibidores de Proteínas Quinases/farmacologia; Tiazóis/farmacologia; Tirosina Quinase da Agamaglobulinemia/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Cristalografia por Raios X; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Linfoma Difuso de Grandes Células B/metabolismo; Linfoma Difuso de Grandes Células B/patologia; Modelos Moleculares; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Relação Estrutura-Atividade; Tiazóis/síntese química; Tiazóis/química; Células Tumorais Cultivadas

Palavras-chave

Activity; B cell lymphoma; BTK inhibitor; Diphenylthiazole; Docking mode

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Linfoma Difuso de Grandes Células B / Inibidores de Proteínas Quinases / Descoberta de Drogas / Tirosina Quinase da Agamaglobulinemia / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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