NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.
J Pharmacol Sci
; 140(2): 193-196, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-31235271
We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dysfunctions, although it, given toward the end of occlusion, was less effective. Systemic administration of NNC before the occlusion also attenuated the infarct and neurological dysfunctions. Our data imply that blood-brain-barrier-permeable T-channel blockers such as NNC are capable of reducing MCAO/R-induced brain damage, and that T-channels are involved in neuronal damage induced by ischemia rather than reperfusion.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
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Lesões Encefálicas
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Bloqueadores dos Canais de Cálcio
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Traumatismo por Reperfusão
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Infarto da Artéria Cerebral Média
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Ciclopropanos
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Naftalenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article