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Revealing the distinct mechanistic binding and activity of 5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazole enantiomers against FGFR1.
Farrokhzadeh, Abdolkarim; Akher, Farideh Badichi; Olotu, Fisayo A; Soliman, Mahmoud E S; Van Heerden, Fanie R.
Afiliação
  • Farrokhzadeh A; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa. soliman@ukzn.ac.za and School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Pietermaritzburg 3209, South Africa. vanhee
  • Akher FB; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa. soliman@ukzn.ac.za and Department of Computer Science, University of Cape Town, Cape Town, South Africa.
  • Olotu FA; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa. soliman@ukzn.ac.za.
  • Soliman MES; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa. soliman@ukzn.ac.za.
  • Van Heerden FR; School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Pietermaritzburg 3209, South Africa. vanheerdenf@ukzn.ac.za.
Phys Chem Chem Phys ; 21(27): 15120-15132, 2019 Jul 10.
Article em En | MEDLINE | ID: mdl-31241637
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Indazóis Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Indazóis Idioma: En Ano de publicação: 2019 Tipo de documento: Article