Progression of <i>JAK2-</i>mutant polycythemia vera to <i>CALR</i>-mutant myelofibrosis severely impacts on disease phenotype and response to therapy.

Holmström, Morten Orebo; Novotny, Guy W; Petersen, Jesper; Aaboe-Jørgensen, Mia; Hasselbalch, Hans Carl; Andersen, Mads H; Nielsen, Signe Ledou; Fassi, Daniel El; Schöllkopf, Claudia

Progression of JAK2-mutant polycythemia vera to CALR-mutant myelofibrosis severely impacts on disease phenotype and response to therapy.

Holmström, Morten Orebo; Novotny, Guy W; Petersen, Jesper; Aaboe-Jørgensen, Mia; Hasselbalch, Hans Carl; Andersen, Mads H; Nielsen, Signe Ledou; Fassi, Daniel El; Schöllkopf, Claudia.

Afiliação

Holmström MO; Department of Hematology, Zealand University Hospital, Roskilde, Denmark.
Novotny GW; National Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark.
Petersen J; Department of Hematology, Herlev University Hospital, Herlev, Denmark.
Aaboe-Jørgensen M; Department of Hematology, Herlev University Hospital, Herlev, Denmark.
Hasselbalch HC; National Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark.
Andersen MH; Department of Hematology, Zealand University Hospital, Roskilde, Denmark.
Nielsen SL; Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Fassi DE; National Center for Cancer Immune Therapy, Department of Hematology, Herlev University Hospital, Herlev, Denmark.
Schöllkopf C; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Leuk Lymphoma ; 60(13): 3296-3299, 2019 12.

Article em En | MEDLINE | ID: mdl-31256699

Assuntos

Calreticulina/genética; Janus Quinase 2/genética; Policitemia Vera/genética; Mielofibrose Primária/genética; Análise Mutacional de DNA; Progressão da Doença; Eritropoetina/uso terapêutico; Transplante de Células-Tronco Hematopoéticas; Humanos; Fatores Imunológicos/uso terapêutico; Masculino; Pessoa de Meia-Idade; Mutação; Policitemia Vera/sangue; Policitemia Vera/patologia; Mielofibrose Primária/sangue; Mielofibrose Primária/patologia; Transplante Homólogo; Resultado do Tratamento

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Policitemia Vera / Calreticulina / Janus Quinase 2 / Mielofibrose Primária Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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