HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder.

Chen, Yuan-Yuan; Lin, Yi; Han, Pei-Yu; Jiang, Shan; Che, Lin; He, Cheng-Yong; Lin, Yu-Chun; Lin, Zhong-Ning

Chen, Yuan-Yuan; Lin, Yi; Han, Pei-Yu; Jiang, Shan; Che, Lin; He, Cheng-Yong; Lin, Yu-Chun; Lin, Zhong-Ning.

Afiliação

Chen YY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
Lin Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
Han PY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
Jiang S; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Che L; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
He CY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
Lin YC; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.
Lin ZN; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.

J Cell Mol Med ; 23(9): 5920-5933, 2019 09.

Article em En | MEDLINE | ID: mdl-31282064

Assuntos

Aflatoxina B1/metabolismo; Ciclo-Oxigenase 2/metabolismo; Fígado Gorduroso/patologia; Hepatite B/patologia; Dinâmica Mitocondrial/fisiologia; Transativadores/metabolismo; Proteínas Virais Reguladoras e Acessórias/metabolismo; Animais; Sistemas CRISPR-Cas; Linhagem Celular Tumoral; Dinaminas/metabolismo; Células Hep G2; Vírus da Hepatite B; Hepatócitos/transplante; Hepatócitos/virologia; Humanos; Gotículas Lipídicas/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias/metabolismo; Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo; Proteínas Quinases/metabolismo; Interferência de RNA; RNA Interferente Pequeno/genética; Proteínas de Ligação a RNA/metabolismo; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo; Transplante Heterólogo

Palavras-chave

aflatoxin B1; cyclooxygenase-2; hepatic steatosis; hepatitis B virus X protein; mitochondrial dynamics; necrosome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transativadores / Aflatoxina B1 / Ciclo-Oxigenase 2 / Proteínas Virais Reguladoras e Acessórias / Fígado Gorduroso / Dinâmica Mitocondrial / Hepatite B Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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