FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases.
J Am Chem Soc
; 141(29): 11358-11362, 2019 07 24.
Article
em En
| MEDLINE
| ID: mdl-31283214
ABSTRACT
A water-soluble self-assembled supramolecular FeII4L4 tetrahedron binds to single stranded DNA, mismatched DNA base pairs, and three-way DNA junctions. Binding of the coordination cage quenches fluorescent labels on the DNA strand, which provides an optical means to detect the interaction and allows the position of the binding site to be gauged with respect to the fluorescent label. Utilizing the quenching and binding properties of the coordination cage, we developed a simple and rapid detection method based on fluorescence quenching to detect unpaired bases in double-stranded DNA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA de Cadeia Simples
/
Compostos Ferrosos
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Pareamento Incorreto de Bases
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article