High birthweight was not associated with altered body composition or impaired glucose tolerance in adulthood.
Acta Paediatr
; 108(12): 2208-2213, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31295357
ABSTRACT
AIM:
To investigate whether a high birthweight was associated with an increased proportion of body fat or with impaired glucose tolerance in adulthood.METHODS:
Our cohort comprised 27 subjects with birthweights of 4500 g or more, and 27 controls with birthweights within ±1 standard deviation scores, born at Uppsala University Hospital 1975-1979. The subjects were 34-40 years old at the time of study. Anthropometric data was collected, and data on body composition was obtained by air plethysmography and bioimpedance and was estimated with a three-compartment model. Indirect calorimetry, blood sampling for fasting insulin and glucose as well as a 75 g oral glucose tolerance test were also performed. Insulin sensitivity was assessed using homoeostasis model assessment 2 and Matsuda index.RESULTS:
There were no differences in body mass index, body composition or insulin sensitivity between subjects with a high birthweight and controls.CONCLUSION:
In this cohort of adult subjects, although limited in size, those born with a moderately high birthweight did not differ from those with birthweights within ±1 standard deviation scores, regarding body composition or glucose tolerance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso ao Nascer
/
Transtornos do Metabolismo de Glucose
/
Adiposidade
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article