Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
Science
; 365(6449)2019 07 12.
Article
em En
| MEDLINE
| ID: mdl-31296738
ABSTRACT
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Nutrição Infantil
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Microbioma Gastrointestinal
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Interações entre Hospedeiro e Microrganismos
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Vida Livre de Germes
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Fenômenos Fisiológicos da Nutrição do Lactente
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Child, preschool
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Humans
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Infant
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article