ADAMTS16 activates latent TGF-ß, accentuating fibrosis and dysfunction of the pressure-overloaded heart.

Yao, Yufeng; Hu, Changqing; Song, Qixue; Li, Yong; Da, Xingwen; Yu, Yubin; Li, Hui; Clark, Ian M; Chen, Qiuyun; Wang, Qing K

Yao, Yufeng; Hu, Changqing; Song, Qixue; Li, Yong; Da, Xingwen; Yu, Yubin; Li, Hui; Clark, Ian M; Chen, Qiuyun; Wang, Qing K.

Afiliação

Yao Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Hu C; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Song Q; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Li Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Da X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Yu Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Li H; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, PR China.
Clark IM; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
Chen Q; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland, OH 44195, USA.
Wang QK; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.

Cardiovasc Res ; 116(5): 956-969, 2020 04 01.

Article em En | MEDLINE | ID: mdl-31297506

Assuntos

Proteínas ADAMTS/metabolismo; Cardiomegalia/enzimologia; Miocárdio/enzimologia; Miofibroblastos/enzimologia; Peptídeos/metabolismo; Precursores de Proteínas/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Remodelação Ventricular; Proteínas ADAMTS/genética; Motivos de Aminoácidos; Animais; Cardiomegalia/genética; Cardiomegalia/patologia; Cardiomegalia/fisiopatologia; Modelos Animais de Doenças; Fibrose; Células HeLa; Humanos; Masculino; Camundongos Endogâmicos C57BL; Miocárdio/patologia; Miofibroblastos/patologia; Peptídeos/genética; Domínios e Motivos de Interação entre Proteínas; Precursores de Proteínas/genética; Transdução de Sinais; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Regulação para Cima

Palavras-chave

ADAMTS16; Cardiac fibrosis; Heart failure; SMAD2/SMAD3; TGF-ß

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Precursores de Proteínas / Fator de Crescimento Transformador beta / Cardiomegalia / Remodelação Ventricular / Miofibroblastos / Proteínas ADAMTS / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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