Food as medicine: Selenium enriched lentils offer relief against chronic arsenic poisoning in Bangladesh.
Environ Res
; 176: 108561, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31299617
ABSTRACT
Chronic arsenic (As) exposure is a major environmental threat to human health affecting >100 million people worldwide. Low blood selenium (Se) increases the risk of As-induced health problems. Our aim was to reduce As toxicity through a naturally Se-rich lentil diet. In a randomized, double-blind, placebo-control trial in Bangladesh, 405 participants chronically exposed to As were enrolled. The intervention arm (Se-group) consumed Se-rich lentils (55⯵g Se/day); the control arm received lentils of similar nutrient profile except with low Se (1.5⯵g Se/day). Anthropometric measurements, blood, urine and stool samples, were taken at baseline, 3 and 6 months; hair at baseline and 6 months after intervention. Morbidity data were collected fortnightly. Measurements included total As in all biological samples, As metabolites in urine, and total Se in blood and urine. Intervention with Se-rich lentils resulted in higher urinary As excretion (pâ¯=â¯0.001); increased body mass index (pâ¯≤â¯0.01), and lower incidence of asthma (pâ¯=â¯0.05) and allergy (pâ¯=â¯0.02) compared to the control group. The Se-group demonstrated increased excretion of urinary As metabolite, dimethylarsinic acid (DMA) at 6 months compared to control group (pâ¯=â¯0.008). Consuming Se-rich lentils can increase As excretion and improve the health indicators in the presence of continued As exposure.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Selênio
/
Intoxicação por Arsênico
/
Lens (Planta)
/
Dieta
Tipo de estudo:
Clinical_trials
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article