Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-ß signaling pathway.

Yin, Zi; Ma, Tingting; Huang, Bowen; Lin, Lehang; Zhou, Yu; Yan, Jinhai; Zou, Yiping; Chen, Sheng

Yin, Zi; Ma, Tingting; Huang, Bowen; Lin, Lehang; Zhou, Yu; Yan, Jinhai; Zou, Yiping; Chen, Sheng.

Afiliação

Yin Z; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, People's Republic of China. yinzi@gdph.org.cn.
Ma T; Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.
Huang B; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Lin L; Medical Research Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.
Zhou Y; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Yan J; Pathology Department, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China.
Zou Y; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Chen S; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Guangzhou, 510080, Guangdong Province, People's Republic of China. cc_pancreas@aliyun.com.

J Exp Clin Cancer Res ; 38(1): 310, 2019 Jul 15.

Article em En | MEDLINE | ID: mdl-31307515

Assuntos

Carcinoma Ductal Pancreático/patologia; Exossomos/genética; MicroRNAs/genética; Neoplasias Pancreáticas/patologia; Proteoglicanas/genética; Receptores de Fatores de Crescimento Transformadores beta/genética; Adulto; Idoso; Animais; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/metabolismo; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Progressão da Doença; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Macrófagos/citologia; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Camundongos; Camundongos Nus; Pessoa de Meia-Idade; Metástase Neoplásica; Transplante de Neoplasias; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

Angiogenesis; Cell invasion; Exosome; M2 macrophage; Metastasis; MicroRNA-501-3p; Pancreatic ductal adenocarcinoma; TGF-ß signaling pathway; TGFBR3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteoglicanas / Receptores de Fatores de Crescimento Transformadores beta / Carcinoma Ductal Pancreático / MicroRNAs / Exossomos Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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