Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice.

Ueda, Hiromichi; Yamaguchi, Osamu; Taneike, Manabu; Akazawa, Yasuhiro; Wada-Kobayashi, Haruko; Sugihara, Ryuta; Yorifuji, Hiroki; Nakayama, Hiroyuki; Omiya, Shigemiki; Murakawa, Tomokazu; Sakata, Yasushi; Otsu, Kinya

Ueda, Hiromichi; Yamaguchi, Osamu; Taneike, Manabu; Akazawa, Yasuhiro; Wada-Kobayashi, Haruko; Sugihara, Ryuta; Yorifuji, Hiroki; Nakayama, Hiroyuki; Omiya, Shigemiki; Murakawa, Tomokazu; Sakata, Yasushi; Otsu, Kinya.

Afiliação

Ueda H; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Yamaguchi O; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Taneike M; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Akazawa Y; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Wada-Kobayashi H; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Sugihara R; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Yorifuji H; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Nakayama H; Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Omiya S; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.
Murakawa T; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.
Sakata Y; Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Otsu K; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, London, United Kingdom.

JACC Basic Transl Sci ; 4(3): 348-363, 2019 Jun.

Article em En | MEDLINE | ID: mdl-31312759

Palavras-chave

CCCP, carbonyl cyanide m-chlorophenyl hydrazine; CpG ODN, unmethylated cytidine-phosphate-guanosine containing oligodeoxynucleotide; CpG, cytidine-phosphate-guanosine; DNA, deoxyribonucleic acid; E6446, (6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole); EdU, 5-ethynyl-2'-deoxyuridine; IL, interleukin; IVSd, end-diastolic interventricular septal wall thickness; LAMP, lysosome-associated membrane protein; LC, microtubule-associated protein light chain; LPS, lipopolysaccharide; LV, left ventricular; TAC, transverse aortic constriction; TLR, Toll-like receptor; TNF, tumor necrosis factor; Toll-like receptor 9; heart failure; mRNA, messenger ribonucleic acid; mitochondria; pressure overload

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article