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Arginine to Lysine Mutations Increase the Aggregation Stability of a Single-Chain Variable Fragment through Unfolded-State Interactions.
Austerberry, James I; Thistlethwaite, Angela; Fisher, Karl; Golovanov, Alexander P; Pluen, Alain; Esfandiary, Reza; van der Walle, Christopher F; Warwicker, Jim; Derrick, Jeremy P; Curtis, Robin.
Afiliação
  • Austerberry JI; Faculty of Biology, Medicine and Health , University of Manchester , Manchester M13 9PT , United Kingdom.
  • Thistlethwaite A; Manchester Institute of Biotechnology , University of Manchester , Manchester M1 7DN , United Kingdom.
  • Fisher K; Faculty of Biology, Medicine and Health , University of Manchester , Manchester M13 9PT , United Kingdom.
  • Golovanov AP; Manchester Institute of Biotechnology , University of Manchester , Manchester M1 7DN , United Kingdom.
  • Pluen A; Manchester Institute of Biotechnology , University of Manchester , Manchester M1 7DN , United Kingdom.
  • Esfandiary R; School of Chemistry , University of Manchester , Manchester M1 7DN , United Kingdom.
  • van der Walle CF; Manchester Pharmacy School , University of Manchester , Manchester M13 9PL , United Kingdom.
  • Warwicker J; Dosage Form Design & Development , AstraZeneca , Gaithersburg , Maryland 20878 , United States.
  • Derrick JP; Dosage Form Design & Development , AstraZeneca , Granta Park , Cambridge CB21 6GH , United Kingdom.
  • Curtis R; Manchester Institute of Biotechnology , University of Manchester , Manchester M1 7DN , United Kingdom.
Biochemistry ; 58(32): 3413-3421, 2019 08 13.
Article em En | MEDLINE | ID: mdl-31314511
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos de Cadeia Única / Desdobramento de Proteína / Agregados Proteicos / Mutação Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos de Cadeia Única / Desdobramento de Proteína / Agregados Proteicos / Mutação Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article