The active site of the <i>Mycobacterium tuberculosis</i> branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.

Bashiri, Ghader; Grove, Tyler L; Hegde, Subray S; Lagautriere, Thomas; Gerfen, Gary J; Almo, Steven C; Squire, Christopher J; Blanchard, John S; Baker, Edward N

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.

Bashiri, Ghader; Grove, Tyler L; Hegde, Subray S; Lagautriere, Thomas; Gerfen, Gary J; Almo, Steven C; Squire, Christopher J; Blanchard, John S; Baker, Edward N.

Afiliação

Bashiri G; Maurice Wilkins Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10805.
Hegde SS; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10805.
Lagautriere T; Maurice Wilkins Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Gerfen GJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10805.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10805.
Squire CJ; Maurice Wilkins Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Blanchard JS; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10805.
Baker EN; Maurice Wilkins Center for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand. Electronic address: ted.baker@auckland.ac.nz.

J Biol Chem ; 294(35): 13158-13170, 2019 08 30.

Article em En | MEDLINE | ID: mdl-31315931

Assuntos

Aminoácidos de Cadeia Ramificada/biossíntese; Hidroliases/metabolismo; Proteínas Ferro-Enxofre/metabolismo; Mycobacterium tuberculosis/química; Aminoácidos de Cadeia Ramificada/química; Sítios de Ligação; Hidroliases/química; Proteínas Ferro-Enxofre/química; Modelos Moleculares; Conformação Molecular; Mycobacterium tuberculosis/metabolismo

Palavras-chave

Mycobacterium tuberculosis; biosynthesis; crystal structure; dihydroxyacid dehydratase; ironsulfur protein; protein stability; protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aminoácidos de Cadeia Ramificada / Hidroliases / Proteínas Ferro-Enxofre / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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