A non-enzymatic amperometric glucose sensor based on the use of graphene frameworks-promoted ultrafine platinum nanoparticles.

Ultrafine platinum nanoparticles are grown on a 3D graphene framework (GF-Pt) via a hydrothermal method. The material, when placed on a glassy carbon electrode (GCE), displays enhanced electrocatalytic activity towards glucose oxidation. This is assumed to be the result of the numerous easily accessible active sites, an enlarged electrochemically active area, and the presence of multiple electron/ion transport channels. The modified GCE can be operated at a low potential (- 0.15 V vs. Ag/AgCl) has linear responses in the 0.1 µM - 0.01 mM and 0.01 mM - 20 mM glucose concentration range, and a 30 nM detection limit. It was applied to the rapid determination of glucose in human serum samples. Graphical abstract Schematic presentation of a glassy carbon electrode modified with ultrafine Pt nanoparticles grown on a graphene framework (GFs-Pt). GFs-Pt presents enhanced electrocatalytic activity towards glucose oxidation. GFs-Pt is used in a sensitive non-enzymatic amperometric glucose sensor.