Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot ß-Arylation of Chromanones with Arylboronic Acids.

ABSTRACT

A total of 47 flavanones were expediently synthesized via one-pot ß-arylation of chromanones, a class of simple ketones possessing chemically unactivated ß sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92%.