Role of Myeloperoxidase of northern snakehead (Channa argus) in Aeromonas veronii infection.
Microb Pathog
; 135: 103622, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31323322
ABSTRACT
Myeloperoxidase (MPO) is a ferrous lysosomal protein with many immune functions that belongs to the heme peroxidase enzyme. In this study, the functions of MPO in the northern snakehead (Channa argus) were investigated by cloning an MPO cDNA sequence with a full length of 3181 bp. Homology analysis showed that northern snakehead MPO gene had the highest (81%) homology with mandarin fish (Siniperca chuatsi). In healthy northern snakehead, the MPO gene was expressed in the head-kidney, kidney, heart, gill, spleen, liver, and muscles but not midgut. After the northern snakehead was infected with Aeromonas veronii, the MPO gene expression varied in different tissues with low level in spleen, liver, gill and muscle, fluctuated in kidney and head-kidney and showed high level in heart. The result indicated that MPO might play an important role in the antimicrobial immune response of the northern snakehead.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Negativas
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Peroxidase
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Doenças dos Peixes
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Peixes
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Aeromonas veronii
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article