The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity.

Gao, Su; Ghoshal, Sarbani; Zhang, Liyan; Stevens, Joseph R; McCommis, Kyle S; Finck, Brian N; Lopaschuk, Gary D; Butler, Andrew A

Gao, Su; Ghoshal, Sarbani; Zhang, Liyan; Stevens, Joseph R; McCommis, Kyle S; Finck, Brian N; Lopaschuk, Gary D; Butler, Andrew A.

Afiliação

Gao S; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2R7, Canada; Department of Metabolism and Aging, Scripps Research Institute, Jupiter, Florida 33458.
Ghoshal S; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
Zhang L; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.
Stevens JR; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
McCommis KS; Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Finck BN; Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Lopaschuk GD; Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.
Butler AA; Department of Metabolism and Aging, Scripps Research Institute, Jupiter, Florida 33458; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104. Electronic address: andrew.butler@health.slu.edu.

J Biol Chem ; 294(36): 13366-13377, 2019 09 06.

Article em En | MEDLINE | ID: mdl-31324719

Assuntos

Modelos Animais de Doenças; Glucose/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Fígado/química; Obesidade/metabolismo; Animais; Dieta Hiperlipídica; Fígado/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/induzido quimicamente; Transdução de Sinais

Palavras-chave

adropin; c-Jun N-terminal kinase (JNK); endoplasmic reticulum stress (ER stress); energy metabolism; gluconeogenesis; insulin receptor substrate 1 (IRS1); insulin resistance; lipogenesis; protein kinase A (PKA); type 2 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos e Proteínas de Sinalização Intercelular / Modelos Animais de Doenças / Glucose / Fígado / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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