Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism.

Maj, Ewa; Trynda, Justyna; Maj, Beata; Gebura, Katarzyna; Bogunia-Kubik, Katarzyna; Chodynski, Michal; Kutner, Andrzej; Wietrzyk, Joanna

Maj, Ewa; Trynda, Justyna; Maj, Beata; Gebura, Katarzyna; Bogunia-Kubik, Katarzyna; Chodynski, Michal; Kutner, Andrzej; Wietrzyk, Joanna.

Afiliação

Maj E; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland. Electronic address: ewa.maj@hirszfeld.pl.
Trynda J; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland.
Maj B; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland.
Gebura K; Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland.
Bogunia-Kubik K; Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland.
Chodynski M; Pharmaceutical Research Institute, 8 Rydygiera, 01-793 Warsaw, Poland.
Kutner A; Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha, 02-097 Warsaw, Poland.
Wietrzyk J; Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla, 53-114 Wroclaw, Poland.

J Steroid Biochem Mol Biol ; 193: 105431, 2019 10.

Article em En | MEDLINE | ID: mdl-31326626

Assuntos

Neoplasias Pulmonares/genética; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteína Supressora de Tumor p53/genética; Vitamina D/análogos & derivados; Vitamina D/farmacologia; Vitaminas/farmacologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/metabolismo; Mutação; Polimorfismo Genético; Receptores de Calcitriol/genética; Receptores de Calcitriol/metabolismo; Vitamina D3 24-Hidroxilase/metabolismo

Palavras-chave

24,24-Dihomo-1,25D3; CYP24A1; NSCLC; PRI-1890; VDDs; VDR polymorphism; Vitamin D derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Vitaminas / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas p21(ras) / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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