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Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Cheng, Zhiming; Valença, Wagner O; Dias, Gleiston G; Scott, Jamie; Barth, Nicole D; de Moliner, Fabio; Souza, Gabriela B P; Mellanby, Richard J; Vendrell, Marc; da Silva Júnior, Eufrânio N.
Afiliação
  • Cheng Z; Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.
  • Valença WO; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Dias GG; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Scott J; Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.
  • Barth ND; Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.
  • de Moliner F; Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.
  • Souza GBP; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
  • Mellanby RJ; Royal (Dick) School of Veterinary Studies, The Roslin Institute, Division of Veterinary Clinical Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, EH25 9RG Roslin, UK.
  • Vendrell M; Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK. Electronic address: marc.vendrell@ed.ac.uk.
  • da Silva Júnior EN; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil. Electronic address: eufranio@ufmg.br.
Bioorg Med Chem ; 27(17): 3938-3946, 2019 09 01.
Article em En | MEDLINE | ID: mdl-31327676
ABSTRACT
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)Hquinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinonas / Produtos Biológicos / Neoplasias Colorretais / Adenocarcinoma / NAD(P)H Desidrogenase (Quinona) / Imagem Óptica / Corantes Fluorescentes Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinonas / Produtos Biológicos / Neoplasias Colorretais / Adenocarcinoma / NAD(P)H Desidrogenase (Quinona) / Imagem Óptica / Corantes Fluorescentes Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article