Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
Bioorg Med Chem
; 27(17): 3938-3946, 2019 09 01.
Article
em En
| MEDLINE
| ID: mdl-31327676
ABSTRACT
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)Hquinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Produtos Biológicos
/
Neoplasias Colorretais
/
Adenocarcinoma
/
NAD(P)H Desidrogenase (Quinona)
/
Imagem Óptica
/
Corantes Fluorescentes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article