Novel cucurbitane-type triterpene saponins from Hemsleya amabilis.
J Asian Nat Prod Res
; 22(1): 30-37, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-31328543
ABSTRACT
The rhizomes of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded three new cucurbitane-type triterpene saponins xuedanosides K-M (1-3) by silica gel column, ODS column, and pre-HPLC techniques. The structure was determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1-3 were evaluated for cytotoxic activity against HeLa and HCT-8 human cancer cell lines and showed significant cytotoxicity with IC50 values of 2.01-14.56 and 8.94-27.48 µM, respectively.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
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Cucurbitaceae
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article