Synthesis of the Core Framework of the Cornexistins by Intramolecular Nozaki-Hiyama-Kishi Coupling.
Molecules
; 24(14)2019 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-31336669
ABSTRACT
A new and direct approach to the construction of the core framework of the herbicidal natural products cornexistin and hydroxycornexistin has been developed. Formation of the nine-membered carbocycle found in the natural products has been accomplished by an intramolecular Nozaki-Hiyama-Kishi reaction between a vinylic iodide and an aldehyde. Good yields of carbocyclic products were obtained from the reaction, but diastereomeric mixtures of allylic alcohols were produced. The cyclisation reaction was successful irrespective of the relative configuration of the stereogenic centres in the cyclisation precursor.
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01-internacional
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MEDLINE
Assunto principal:
Técnicas de Química Sintética
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Furanos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article