Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?
Respir Med Case Rep
; 28: 100906, 2019.
Article
em En
| MEDLINE
| ID: mdl-31341766
ABSTRACT
A diagnosis of silicosis is made on the basis of exposure and typical radiological findings, according to the ILO's International Classification of Radiographs of Pneumoconiosis. Radiological patterns of silicosis can, however, resemble sarcoidosis. Sarcoidosis is a multi-systemic disorder of unknown etiology, although a role for initiating inorganic triggers such as metals or silica has been suggested. In this case report, we illustrate a patient previously diagnosed with silicosis based on exposure and radiological features, progressive under immunosuppressive treatment. In view of these findings, an open lung biopsy was performed and revealed sarcoidosis. The patient was effectively treated with infliximab. Further analysis showed the presence of silica in the granulomas. Sensitization to silica was also demonstrated, suggesting an association between silica exposure and sarcoidosis in this patient.
18 F-FDG PET/CT, 18F-fluorodeoxyglucose by positron emission tomography/computed tomography; CBD, Chronic beryllium disease; DLCO, diffusing capacity of the lung for carbon monoxide; EDXA, Energy-dispersive X-ray spectroscopy analysis; FVC, Forced Vital Capacity; HRCT, High-resolution computed tomography; Infliximab; LPT, Lymphocyte proliferation test; Sarcoidosis; Sarcoidosis phenotypes; Silica; Silicosis
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article