Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos.
Hum Immunol
; 81(9): 557-559, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31345701
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (Nâ¯=â¯82) and rural communities (Nâ¯=â¯30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43⯱â¯2.22% by ML; 53.57% of Native American haplotypes) and European (39.58⯱â¯3.70% by ML; 27.68% of European haplotypes), and a virtually absent African genetic component (0.00⯱â¯4.93% by ML; but 11.16% of African haplotypes).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
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Etnicidade
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Genética Populacional
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Antígenos HLA
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article