Mass Spectrometry-Based Tissue Imaging of Small Molecules.
Adv Exp Med Biol
; 1140: 99-109, 2019.
Article
em En
| MEDLINE
| ID: mdl-31347043
ABSTRACT
Mass spectrometry imaging (MSI) of tissue samples is a promising analytical tool that has quickly become associated with biomedical and pharmacokinetic studies. It eliminates several labor-intensive protocols associated with more classical imaging techniques, and provides accurate, histological data at a rapid pace. Because mass spectrometry is used as the readout, MSI can be applied to almost any molecule, especially those that are biologically relevant. Many examples of its utility in the study of peptides and proteins have been reported; here we discuss its value in the mass range of small molecules. We explore its success and potential in the analysis of lipids, medicinals, and metal-based compounds by featuring representative studies from mass spectrometry imaging laboratories around the globe.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Massas
/
Preparações Farmacêuticas
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Lipídeos
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Metais
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article