Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torreón, Saltillo and rural Coahuila.
Hum Immunol
; 81(9): 492-495, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-31350053
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (Nâ¯=â¯72), Torreón (Nâ¯=â¯396) and rural communities (Nâ¯=â¯216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72⯱â¯4.18% by ML; 37.49% of European haplotypes) and Native American (45.01⯱â¯2.69% by ML; 42.98% of Native American haplotypes), while African genetic component is less apparent (5.27⯱â¯1.88% by ML; 9.92% of African haplotypes).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Etnicidade
/
Alelos
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Antígenos HLA
Limite:
Humans
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article