Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation.

Briggs, Emma; Crouch, Kathryn; Lemgruber, Leandro; Hamilton, Graham; Lapsley, Craig; McCulloch, Richard

Briggs, Emma; Crouch, Kathryn; Lemgruber, Leandro; Hamilton, Graham; Lapsley, Craig; McCulloch, Richard.

Afiliação

Briggs E; The Wellcome Centre for Integrative Parasitology, University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.
Crouch K; The Wellcome Centre for Integrative Parasitology, University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.
Lemgruber L; The Wellcome Centre for Integrative Parasitology, University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.
Hamilton G; Glasgow Polyomics, University of Glasgow, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Rd, Bearsden G61 1QH, UK.
Lapsley C; The Wellcome Centre for Integrative Parasitology, University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.
McCulloch R; The Wellcome Centre for Integrative Parasitology, University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, UK.

Nucleic Acids Res ; 47(17): 9180-9197, 2019 09 26.

Article em En | MEDLINE | ID: mdl-31350892

Assuntos

Antígenos de Protozoários/genética; Instabilidade Genômica/genética; Ribonuclease H/genética; Iniciação da Transcrição Genética; Animais; Antígenos de Protozoários/imunologia; DNA/química; DNA/genética; Dano ao DNA/genética; Replicação do DNA/genética; Regulação da Expressão Gênica/genética; Humanos; Conformação de Ácido Nucleico; RNA/química; RNA/genética; RNA Polimerase I/genética; RNA Polimerase II/genética; Ribonuclease H/química; Ribonuclease H/imunologia; Trypanosoma brucei brucei/genética; Trypanosoma brucei brucei/imunologia; Trypanosoma brucei brucei/patogenicidade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonuclease H / Instabilidade Genômica / Iniciação da Transcrição Genética / Antígenos de Protozoários Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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