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Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Santos, Elda Gonçalves; Gonçalves, Reggiani V; Souza-Silva, Thaiany G; Maldonado, Izabel R S C; Santos, Eliziária C; Talvani, André; Natali, Antônio J; Novaes, Rômulo D.
Afiliação
  • Santos EG; Department of Structural Biology, Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, MG, 37130-001, Brazil.
  • Gonçalves RV; Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil.
  • Souza-Silva TG; Department of Structural Biology, Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, MG, 37130-001, Brazil.
  • Maldonado IRSC; Department of General Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil.
  • Santos EC; School of Medicine, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, 39100-000, Brazil.
  • Talvani A; Department of Biological Science and NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35400-000, Brazil.
  • Natali AJ; Department of Physical Education, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil.
  • Novaes RD; Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil.
Parasitology ; 146(13): 1655-1664, 2019 11.
Article em En | MEDLINE | ID: mdl-31362797
Considering a potential exercise-drug interaction, we investigated whether exercise training could improve the efficacy of specific antiparasitic chemotherapy in a rodent model of Chagas disease. Wistar rats were randomized into five groups: sedentary and uninfected (CT); sedentary and infected (SI); sedentary, infected and treated (SIT); trained and infected (TI); trained, infected and treated (TIT). After 9-weeks running training, the animals were infected with T. cruzi and followed up for 4 weeks, receiving 100 mg kg-1 day-1 benznidazole. No evidence of myocarditis was observed in CT animals. TI animals exhibited reduced parasitemia, myocarditis, and reactive tissue damage compared to SI animals, in addition to increased IFN-γ, IL-4, IL-10, heart non-protein antioxidant (NPA) levels and glutathione-s transferase activity (P < 0.05). The CT, SIT and TIT groups presented similar reductions in parasitemia, cytokines (IFN-γ, TNF-α, IL-4, IL-10, IL-17 and MCP-1), inflammatory infiltrate, oxidative heart damage and antioxidant enzymes activity compared to SI and TI animals, as well as reduced heart microstructural remodeling (P < 0.05). By modulating heart inflammation and redox metabolism, exercise training exerts a protective effect against T. cruzi infection in rats. However, the antiparasitic and cardioprotective effects of benznidazole chemotherapy are more pronounced, determining similar endpoints in sedentary and trained T. cruzi-infected rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Cardiotônicos / Doença de Chagas / Nitroimidazóis / Antiparasitários Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Cardiotônicos / Doença de Chagas / Nitroimidazóis / Antiparasitários Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article