Acylpeptide hydrolase (APEH) sequence variants with potential impact on the metabolism of the antiepileptic drug valproic acid.

Tsortouktzidis, Despina; Grundke, Kathleen; Till, Claudia; Korwitz-Reichelt, Anne; Sass, Jörn Oliver

Tsortouktzidis, Despina; Grundke, Kathleen; Till, Claudia; Korwitz-Reichelt, Anne; Sass, Jörn Oliver.

Afiliação

Tsortouktzidis D; Research Group Inborn Errors of Metabolism, Department of Natural Sciences,, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359, Rheinbach, Germany.
Grundke K; Division of Clinical Chemistry & Biochemistry, University Children's Hospital and Children's Research Center, Zürich, Switzerland.
Till C; Research Group Inborn Errors of Metabolism, Department of Natural Sciences,, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359, Rheinbach, Germany.
Korwitz-Reichelt A; Research Group Inborn Errors of Metabolism, Institute for Functional Gene Analytics (IFGA), Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany.
Sass JO; Research Group Inborn Errors of Metabolism, Department of Natural Sciences,, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, 53359, Rheinbach, Germany.

Metab Brain Dis ; 34(6): 1629-1634, 2019 12.

Article em En | MEDLINE | ID: mdl-31363986

Assuntos

Anticonvulsivantes/farmacocinética; Peptídeo Hidrolases/genética; Ácido Valproico/farmacocinética; Genótipo; Células HEK293; Humanos; Modelos Moleculares; Peptídeo Hidrolases/metabolismo

Palavras-chave

Acylpeptide hydrolase; Aminoacylase; Carbapenem; Pharmacogenetics; Polymorphism; Valproic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Ácido Valproico / Anticonvulsivantes Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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