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Clinical and Prognostic Significance of Neoplastic Spindle Cells in Gallbladder Cancer.
Midorikawa, Ryuta; Hisaka, Toru; Sakai, Hisamune; Nomura, Yoriko; Goto, Yuichi; Sato, Toshihiro; Kawahara, Ryuichi; Ishikawa, Hiroto; Fujita, Fumihiko; Yasunaga, Masafumi; Tanigawa, Masahiko; Naito, Yoshiki; Akiba, Jun; Yano, Hirohisa; Tanaka, Hiroyuki; Akagi, Yoshito; Okuda, Koji.
Afiliação
  • Midorikawa R; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Hisaka T; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan midorikawa_ryuuta@med.kurume-u.ac.jp.
  • Sakai H; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Nomura Y; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Goto Y; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Sato T; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Kawahara R; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Ishikawa H; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Fujita F; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Yasunaga M; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Tanigawa M; Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.
  • Naito Y; Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.
  • Akiba J; Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.
  • Yano H; Department of Pathology, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Tanaka H; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Akagi Y; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
  • Okuda K; Department of Surgery, Faculty of Medicine, Kurume University, Kurume, Japan.
Anticancer Res ; 39(8): 4561-4568, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31366560
ABSTRACT
BACKGROUND/

AIM:

Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND

METHODS:

Specimens were obtained from 62 patients with gallbladder cancer who underwent surgery. The emergence of NSCs and their correlation with clinicopathological factors, prognosis, and EMT markers was evaluated.

RESULTS:

The NSC grade correlated with tumor size, preoperative CA19-9, surgical margin, the degree of differentiation, the depth of invasion, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion. Multivariate analysis of overall survival showed that NSCs were an independent prognostic factor. A correlation between NSCs and EMT was also suggested.

CONCLUSION:

NSCs are an independent prognostic factor for patients with postoperative gallbladder cancer, which also suggests a correlation between NSCs and EMT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prognóstico / Biomarcadores Tumorais / Neoplasias da Vesícula Biliar / Invasividade Neoplásica Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prognóstico / Biomarcadores Tumorais / Neoplasias da Vesícula Biliar / Invasividade Neoplásica Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article