Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production.

Slawinska-Brych, Adrianna; Zdzisinska, Barbara; Czerwonka, Arkadiusz; Mizerska-Kowalska, Magdalena; Dmoszynska-Graniczka, Magdalena; Stepulak, Andrzej; Gagos, Mariusz

Slawinska-Brych, Adrianna; Zdzisinska, Barbara; Czerwonka, Arkadiusz; Mizerska-Kowalska, Magdalena; Dmoszynska-Graniczka, Magdalena; Stepulak, Andrzej; Gagos, Mariusz.

Afiliação

Slawinska-Brych A; Department of Cell Biology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland. Electronic address: adrianna.slawinska-brych@poczta.umcs.lublin.pl.
Zdzisinska B; Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
Czerwonka A; Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
Mizerska-Kowalska M; Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.
Dmoszynska-Graniczka M; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
Stepulak A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
Gagos M; Department of Cell Biology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland.

Biochim Biophys Acta Gen Subj ; 1863(11): 129408, 2019 11.

Article em En | MEDLINE | ID: mdl-31386885

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Flavonoides/farmacologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Mieloma Múltiplo; Proteínas de Neoplasias/metabolismo; Propiofenonas/farmacologia; Receptores de Interleucina-6/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Linhagem Celular Tumoral; Humanos; MAP Quinase Quinase 4/metabolismo; Mieloma Múltiplo/tratamento farmacológico; Mieloma Múltiplo/metabolismo; Mieloma Múltiplo/patologia

Palavras-chave

Apoptosis; MAPKs; Multiple myeloma; ROS; VEGF; Xanthohumol; sIL-6R

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propiofenonas / Flavonoides / Apoptose / Receptores de Interleucina-6 / Sistema de Sinalização das MAP Quinases / Fator A de Crescimento do Endotélio Vascular / Proliferação de Células / Mieloma Múltiplo / Proteínas de Neoplasias Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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