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Genomic Regions Associated with IgE Levels against Culicoides spp. Antigens in Three Horse Breeds.
François, Liesbeth; Hoskens, Hanne; Velie, Brandon D; Stinckens, Anneleen; Tinel, Susanne; Lamberigts, Chris; Peeters, Liesbet; Savelkoul, Huub F J; Tijhaar, Edwin; Lindgren, Gabriella; Janssens, Steven; Ducro, Bart J; Buys, Nadine; Schurink, And Anouk.
Afiliação
  • François L; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
  • Hoskens H; Department of Human Genetics, KU Leuven, B-3000 Leuven, Belgium.
  • Velie BD; School of Life & Environmental Sciences, B19-603 University of Sydney, Sydney, NSW 2006,Australia.
  • Stinckens A; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
  • Tinel S; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
  • Lamberigts C; Research Group Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, B-3001 Leuven, Belgium.
  • Peeters L; Biomedical Research Institute, Hasselt University, B-3590 Diepenbeek, Belgium.
  • Savelkoul HFJ; Cell Biology and Immunology Group, Wageningen University & Research, 6700 AH Wageningen, The Netherlands.
  • Tijhaar E; Cell Biology and Immunology Group, Wageningen University & Research, 6700 AH Wageningen, The Netherlands.
  • Lindgren G; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
  • Janssens S; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.
  • Ducro BJ; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
  • Buys N; Animal Breeding and Genomics, Wageningen University & Research, 6700 AH Wageningen, The Netherlands.
  • Schurink AA; Livestock Genetics, Department of Biosystems, KU Leuven, B-3001 Leuven, Belgium.
Genes (Basel) ; 10(8)2019 08 08.
Article em En | MEDLINE | ID: mdl-31398914
ABSTRACT
Insect bite hypersensitivity (IBH), which is a cutaneous allergic reaction to antigens from Culicoides spp., is the most prevalent skin disorder in horses. Misdiagnosis is possible, as IBH is usually diagnosed based on clinical signs. Our study is the first to employ IgE levels against several recombinant Culicoides spp. allergens as an objective, independent, and quantitative phenotype to improve the power to detect genetic variants that underlie IBH. Genotypes of 200 Shetland ponies, 127 Icelandic horses, and 223 Belgian Warmblood horses were analyzed while using a mixed model approach. No single-nucleotide polymorphism (SNP) passed the Bonferroni corrected significance threshold, but several regions were identified within and across breeds, which confirmed previously identified regions of interest and, in addition, identifying new regions of interest. Allergen-specific IgE levels are a continuous and objective phenotype that allow for more powerful analyses when compared to a case-control set-up, as more significant associations were obtained. However, the use of a higher density array seems necessary to fully employ the use of IgE levels as a phenotype. While these results still require validation in a large independent dataset, the use of allergen-specific IgE levels showed value as an objective and continuous phenotype that can deepen our understanding of the biology underlying IBH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Polimorfismo de Nucleotídeo Único / Doenças dos Cavalos / Cavalos / Hipersensibilidade / Mordeduras e Picadas de Insetos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Polimorfismo de Nucleotídeo Único / Doenças dos Cavalos / Cavalos / Hipersensibilidade / Mordeduras e Picadas de Insetos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article