Structural and Biological Basis of Small Molecule Inhibition of <i>Escherichia coli</i> LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis.

Ma, Xiaolei; Prathapam, Ramadevi; Wartchow, Charles; Chie-Leon, Barbara; Ho, Chi-Min; De Vicente, Javier; Han, Wooseok; Li, Min; Lu, Yipin; Ramurthy, Savithri; Shia, Steven; Steffek, Micah; Uehara, Tsuyoshi

Structural and Biological Basis of Small Molecule Inhibition of Escherichia coli LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis.

Ma, Xiaolei; Prathapam, Ramadevi; Wartchow, Charles; Chie-Leon, Barbara; Ho, Chi-Min; De Vicente, Javier; Han, Wooseok; Li, Min; Lu, Yipin; Ramurthy, Savithri; Shia, Steven; Steffek, Micah; Uehara, Tsuyoshi.

ACS Infect Dis ; 6(6): 1480-1489, 2020 06 12.

Article em En | MEDLINE | ID: mdl-31402665

Assuntos

Aciltransferases; Proteínas de Escherichia coli; Escherichia coli; Aciltransferases/antagonistas & inibidores; Aciltransferases/genética; Sítios de Ligação; Escherichia coli/enzimologia; Escherichia coli/genética; Proteínas de Escherichia coli/antagonistas & inibidores; Lipídeo A; Lipopolissacarídeos

Palavras-chave

Escherichia coli; LpxD; X-ray crystallography; antibiotic discovery; lipopolysaccharide biosynthesis; on-target antibacterial activity; small molecule inhibition; surface plasmon resonance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aciltransferases / Proteínas de Escherichia coli / Escherichia coli Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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