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Isavuconazole Diffusion in Infected Human Brain.
Rouzaud, Claire; Jullien, Vincent; Herbrecht, Anne; Palmier, Bruno; Lapusan, Simona; Morgand, Marjolaine; Guéry, Romain; Dureault, Amélie; Danion, François; Puget, Stéphanie; Goldwirt, Lauriane; Lanternier, Fanny; Lortholary, Olivier.
Afiliação
  • Rouzaud C; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Jullien V; Hôpital Européen Georges-Pompidou University Hospital, Department of Pharmacolgy, AP-HP, Paris University, Paris, France.
  • Herbrecht A; Department of Neurosurgery, AP-HP, Bicêtre Hospital, Paris, France.
  • Palmier B; Faculté des Sciences Pharmaceutiques et Biologiques, EA4475-Pharmacologie de la Circulation Cérébrale, Paris University, Paris, France.
  • Lapusan S; Department of Hematology and Cellular Therapy, AP-HP, Saint-Antoine Hospital, Paris, France.
  • Morgand M; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Guéry R; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Dureault A; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Danion F; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Puget S; Necker-Enfants Malades University Hospital, Department of Neurosurgery, AP-HP, Paris University, Paris, France.
  • Goldwirt L; Hôpital Européen Georges-Pompidou University Hospital, Department of Pharmacolgy, AP-HP, Paris University, Paris, France.
  • Lanternier F; Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris University, Paris, France.
  • Lortholary O; Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.
Antimicrob Agents Chemother ; 63(10)2019 10.
Article em En | MEDLINE | ID: mdl-31405852
ABSTRACT
We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Encéfalo / Doença Granulomatosa Crônica / Nitrilas Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Encéfalo / Doença Granulomatosa Crônica / Nitrilas Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article