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Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for ß-thalassaemia.
Mettananda, Sachith; Yasara, Nirmani; Fisher, Christopher A; Taylor, Stephen; Gibbons, Richard; Higgs, Doug.
Afiliação
  • Mettananda S; Department of Paediatrics, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka. sachith.mettananda@kln.ac.lk.
  • Yasara N; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. sachith.mettananda@kln.ac.lk.
  • Fisher CA; Department of Paediatrics, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka.
  • Taylor S; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK.
  • Gibbons R; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Higgs D; Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK.
Sci Rep ; 9(1): 11649, 2019 08 12.
Article em En | MEDLINE | ID: mdl-31406232
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia beta / Alfa-Globinas / Gama-Globinas / Inibidores de Histona Desacetilases / Vorinostat Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia beta / Alfa-Globinas / Gama-Globinas / Inibidores de Histona Desacetilases / Vorinostat Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article