[Medicinal Complex Therapy - Drug Interaction of Valproate and Dipyrone]. / Medikamentöse Komplextherapie ­ Arzneimittelinteraktionen von Valproat und Metamizol.

ABSTRACT

The clinical relevance of the drug interaction between valproic acid and dipyrone is presented in the context of a gerontopsychiatric case. It is assumed that dipyrone at a dose of 4 g/d has a relevant influence on the valproate level and the associated clinical outcome. This may be due to a possible induction of CYP2B6 and increased valproate metabolism. In the case of a treatment of valproate combined with dipyrone, a close monitoring of the valproate level is recommended.