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Evaluation of a Series of ß-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.
Oehlrich, Daniel; Peschiulli, Aldo; Tresadern, Gary; Van Gool, Michiel; Vega, Juan Antonio; De Lucas, Ana Isabel; Alonso de Diego, Sergio A; Prokopcova, Hana; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Rombouts, Frederik J R; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie J M; Trabanco, Andrés A.
Afiliação
  • Oehlrich D; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Peschiulli A; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Tresadern G; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Gool M; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
  • Vega JA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
  • De Lucas AI; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
  • Alonso de Diego SA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
  • Prokopcova H; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Austin N; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Brandt S; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Surkyn M; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • De Cleyn M; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Vos A; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Rombouts FJR; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Macdonald G; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Moechars D; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Gijsen HJM; Medicinal Chemistry, Discovery Sciences, Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Trabanco AA; Discovery Sciences Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain.
ACS Med Chem Lett ; 10(8): 1159-1165, 2019 Aug 08.
Article em En | MEDLINE | ID: mdl-31413800
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article