TEIPP peptides: exploration of unTAPped cancer antigens.
Oncoimmunology
; 8(8): 1599639, 2019.
Article
em En
| MEDLINE
| ID: mdl-31413908
ABSTRACT
The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion mechanism in human cancers. Two recent papers describe which 'hidden' antigens we might exploit to target these escaped cancer variants by CD8 T cells. These unTAPped peptides are now ready for clinical testing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article