Inhibition of CREB-mediated ZO-1 and activation of NF-&#954;B-induced IL-6 by colonic epithelial MCT4 destroys intestinal barrier function.

Zhang, Shunxian; Xu, Wanfu; Wang, Hongli; Cao, Meiwan; Li, Musheng; Zhao, Junhong; Hu, Yan; Wang, Yaodong; Li, Songyu; Xie, Yuanwen; Chen, Guanhua; Liu, Ruitao; Cheng, Yang; Xu, Zhaohui; Zou, Kejian; Gong, Sitang; Geng, Lanlan

Inhibition of CREB-mediated ZO-1 and activation of NF-κB-induced IL-6 by colonic epithelial MCT4 destroys intestinal barrier function.

Zhang, Shunxian; Xu, Wanfu; Wang, Hongli; Cao, Meiwan; Li, Musheng; Zhao, Junhong; Hu, Yan; Wang, Yaodong; Li, Songyu; Xie, Yuanwen; Chen, Guanhua; Liu, Ruitao; Cheng, Yang; Xu, Zhaohui; Zou, Kejian; Gong, Sitang; Geng, Lanlan.

Afiliação

Zhang S; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Xu W; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Wang H; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Cao M; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Li M; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zhao J; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Hu Y; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Wang Y; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Li S; Department of Anesthesiology, Hainan General Hospital, Haikou, China.
Xie Y; Department of Gastroenterology, Kunshan affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, China.
Chen G; Department of Clinical Laboratory, Qionghai Hospital of Traditional Chinese Medicine, Qionghai, China.
Liu R; Department of Anorectal, Qionghai Hospital of Traditional Chinese Medicine, Qionghai, China.
Cheng Y; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Xu Z; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Zou K; Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Gong S; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Geng L; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Cell Prolif ; 52(6): e12673, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31418947

Assuntos

Epitélio/efeitos dos fármacos; Interleucina-6/metabolismo; Transportadores de Ácidos Monocarboxílicos/metabolismo; Proteínas Musculares/metabolismo; Proteína da Zônula de Oclusão-1/metabolismo; Células CACO-2; Colo/metabolismo; Humanos; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; NF-kappa B/efeitos dos fármacos; NF-kappa B/metabolismo; Fator de Transcrição RelA/farmacologia; Fator de Necrose Tumoral alfa/farmacologia; Proteína da Zônula de Oclusão-1/efeitos dos fármacos

Palavras-chave

CREB; IL-6; ZO-1; inflammatory bowel disease; monocarboxylate transporter 4; nuclear factor-κB

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Transportadores de Ácidos Monocarboxílicos / Epitélio / Proteína da Zônula de Oclusão-1 / Proteínas Musculares Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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