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Design, synthesis and biological evaluation of 3,5-dimethylisoxazole and pyridone derivatives as BRD4 inhibitors.
Rong, Juan; Feng, Zhan-Zhan; Shi, Yao-Jie; Ren, Jing; Xu, Ying; Wang, Ning-Yu; Xue, Qiang; Liu, Kun-Lin; Zhou, Shu-Yan; Wei, Wei; Yu, Luo-Ting.
Afiliação
  • Rong J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Feng ZZ; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Shi YJ; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Ren J; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Xu Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang NY; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Xue Q; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Liu KL; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Zhou SY; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wei W; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yu LT; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: yuluot@scu.edu.cn.
Bioorg Med Chem Lett ; 29(19): 126577, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31421967
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Fatores de Transcrição / Desenho de Fármacos / Leucemia / Proteínas de Ciclo Celular / Isoxazóis / Antineoplásicos Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Fatores de Transcrição / Desenho de Fármacos / Leucemia / Proteínas de Ciclo Celular / Isoxazóis / Antineoplásicos Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article